What role does the dopamine reward pathway play in addiction?

What role does the dopamine reward pathway play in addiction?

• A. Substances increase dopamine signaling in the mesolimbic pathway from the ventral tegmental area to the nucleus accumbens, reinforcing use; repeated exposure leads to neuroadaptations that drive cravings.
• B. Dopamine signaling is decreased with drug use, reducing reward.
• C. Addiction is unrelated to dopamine.
• D. Serotonin is the only neurotransmitter involved in reward.

Answer: (A)